Research focus
Our research group focuses on the development and application of a broad range of advanced proteomic approaches for the analysis of complex biological samples and the study of molecular mechanisms in various biological systems.
We apply these proteomic methods to the analysis of plant materials, tissues, biological fluids, cellular models, and animal organisms. Our work includes the characterization of qualitative and quantitative changes in proteomes associated with physiological and pathological processes, cellular stress responses, and the mechanisms of action of biologically active compounds.
An integral part of our research is the development of sample preparation methods, separation strategies, and bioinformatic workflows for the analysis of highly complex datasets. We also integrate proteomic data with metabolomic and lipidomic analyses to achieve a more comprehensive biological interpretation of the studied systems.
For our analyses, we use modern LC–MS/MS instrumentation with ion mobility and advanced tools for data processing, statistical evaluation, and biological interpretation.
Research leader
Team members
- Ivo Chamrád
- Jaroslava Friedecká
- Hana Svobodová
- Radim Simerský (Oddělení chemické biologie)
- Natálie Zemánková